5. Severe Lower Back Pain
Arguably the most notorious reason for absences from work, and misery in general, from every corner of the world. Most people will suffer from some type of back problem at some point in their lives, though these are usually easily solved.
The severe lower back pain brought on by this autoimmune deficiency, however, is a whole different ball game. Given the impact on the muscles, the support structure which keeps a person upright and stable is deeply interrupted, causing imbalances and even compression of the spine.
The resulting disc prolapses, wedging or compression fractures which may occur, can cause a person significant pain, constant discomfort and force huge changes to the level of activity that one might be used to. Back pain, when a cure is possible, is one of the worst ailments to bear, and so that is multiplied somewhat when the outlook for a cure is altogether much bleaker entirely.